Don Juan de Palafox y Mendoza (1600-1659), was the nineth Bishop of Puebla de los Angeles and the most famous one ever because his titanic labor done in New Spain and Puebla done just in nine years (1640-1649). Being bishop of Puebla made its golden period by building the Cathedral Church, three schools and seminars, built his famous library, reorganized the whole Catholic Church in the New Spain according to Council of Trento leading lines (1563), built two hospitals, repaired thirty churches, gave his name to several street orphans, visited three times the whole Puebla province, judged two viceroys in the name of the King, was Bishop of Mexico City and was Chief Commander of the Spanish Army. He spoke perfeclty five european languages and got to know perfectly the customs and lifes of the mexican natives than he was able to wrote down a famous book about them. Poet, builder, lawyer, educator, arts sponsor, administrator, human being, cristian, father of souls, ... Renassance man.

Friar Toribio de Benavente (1490-1568) named by native people as "Motolinia", means "the poorest", was the franciscan founder of Puebla in April 16th, 1531. He said the first Mass to bless the city, traced the new city and he was an active missionary in Mexico. He wrote a book about the Aztec Culture and the Evangelisation Movement done by the missionaries named "Historia de los Indios de la Nueva Espagna" (1558) and it is an important reference book in Mexican History.

Saint Jose Maria de Yermo y Parres (1851-1904) was a priest who started out a amazing charitable work among the orphans and poor in many mexican cities as Leon, Puebla, Merida and others. He was called the "Giant of Charity" because his apostolic work done in everywhere was needed by building institutes and schools to aged people, women and homeless. Moved his headquaters to Puebla 1889 to continue his labor and died there. He was canonized by Pope John Paul II in 2000.